Sodium thio sulphate : Preparation , physical & chemical properties , pharmaceutical uses , storage condition.

 

 Sodium Thio Sulphate [Na₂S₂O₃.5H₂O]

Sodium thio sulphate is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. For cyanide poisoning it is often used after the medication sodium nitrite and typically only recommended for severe cases.

Preparation

* It can also prepared by passing sulphur dioxide into sodium sulphide.

2Na₂S + 3SO₂  → 2Na₂S₂O₃ + 1/2 S₂

* one half of a concentrated solution of sodium carbonate is saturated with Sulphur dioxide and the other half added to it then sodium sulphide is formed.

Na₂CO₃ + 2SO₂ + H₂O → 2NaHSO₃ + CO₂


Na₂CO₃ + 2NaHSO →2Na₂S₂O₃ + H₂O + CO↑

Physical property

* it is colourless odourless and transparent crystalline powder.

* it have bitter taste.

* it is very soluble in water and insoluble in alcohol.

* it have melting point 56℃.

*In its anhydrous form, sodium thiosulfate has a molar mass of 158.11 grams per mole. The more commonly available pentahydrate from, Na2S2O3.5H2O has a molar mass of 248.18 g/mol.

*It has a white, crystalline appearance as a solid and is odourless.

*The density of sodium thiosulfate corresponds to 1.667 grams per cubic centimetres.

Chemical property

* on heating it decompose into sodium sulphite and sulphur dioxide .

*It reduce iodine per maɡnet dichromate and ferrous salt.

2I₂ + Na₂S₂O₃.H₂O → 4HI + 2NaHSO₄

Pharmaceutical uses

* it is used as antioxidant.

* it is used in reducing agent.

* it is used in laboratory .

*it is used an antidote for cyanide poisoning.

* it is used as antifungal agent.

* it is used as antichlor for remove excess of chlorine.

* it is also used in extraction of gold and silver from ores.

Storage condition

It must be stored in tightly closed container.





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